Marco Colombo

Experimental area · proceed at your own risk!

Research papers

P. Boczki, M. Colombo, J. Weiner, I. Rapöhn, M. Lacher, W. Kiess, M. Hanschkow, A. Körner and K. Landgraf Inhibition of AHCY impedes proliferation and differentiation of mouse and human adipocyte progenitor cells Adipocyte, 13 (1), 2290218, 2024
R. Ott, R. Stein, H.H. Hauta-alus, J. Ronkainen, S. Fernández-Barroso, U. Spielau, H. Kirsten, T. Poulain, P.E. Melton, L.K. Küpers, H. Azaryah, M. Colombo, K. Landgraf, E.W. Tobi, T. O'Sullivan, R-C. Huang, C. Campoy, C. Winkler, J. Vioque, M. Vrijheid, W. Kiess, A. Körner, S. Sebert, M-R. Jarvelin, A-G. Ziegler and S. Hummel Epigenome-wide meta-analysis reveals associations between dietary glycemic index and glycemic load and DNA methylation in children and adolescents of different body sizes Diabetes Care, 46 (11), 2067–2075, 2023
C. Hammel, R. Stein, J. Kratzsch, M. Vogel, A.J. Eckert, R.D. Triatin, M. Colombo, C. Meigen, R. Baber, J. Stanik, U. Spielau, A. Stoltze, K. Wirkner, A. Tönjes, H. Snieder, R.W. Holl, M. Stumvoll, M. Blüher, W. Kiess and A. Körner Variation of fasting indices of glucose-insulin-metabolism across life span and prediction of glycemic deterioration in children with obesity from new diagnostic cut-offs The Lancet Regional Health - Europe, 30, 100652, 2023
A. Iakovliev, S. McGurnaghan, C. Hayward, M. Colombo, D. Lipschutz, A. Spiliopoulou, H.M. Colhoun and P.M. McKeigue Genome-wide aggregated trans- effects on risk of type 1 diabetes: a test of the 'omnigenic' sparse effector hypothesis of complex trait genetics American Journal of Human Genetics, 110 (6), 913-926, 2023
R. Stein, F. Koutny, J. Riedel, N. Dörr, K. Meyer, M. Colombo, M. Vogel, C.H. Anderwald, M. Blüher, W. Kiess, A. Körner and D. Weghuber Single Point Insulin Sensitivity Estimator (SPISE) as a prognostic marker for emerging dysglycemia in children with overweight/obesity Metabolites, 13 (1), 100, 2023
L.K. Küpers, S. Fernández-Barrés, G. Mancano, L. Johnson, R. Ott, J. Vioque, M. Colombo, K. Landgraf, E.W. Tobi, A. Körner, R. Gaillard, J.H.M. de Vries, V.W.V. Jaddoe, M. Vrijheid, G.C. Sharp and J.F. Felix Maternal dietary glycemic index and glycemic load in pregnancy and offspring cord blood DNA methylation Diabetes Care, 45 (8), 1822-1832, 2022
E. Valo°, M. Colombo°, N. Sandholm, S.J. McGurnaghan, L.A.K. Blackbourn, D. Dunger, P.M. McKeigue, C. Forsblom P-H. Groop, H.M. Colhoun, C. Turner and R.N. Dalton on behalf of the SDRNT1BIO Investigators and FinnDiane Study Group Effect of serum sample storage temperature on metabolomic and proteomic biomarkers Scientific Reports, 12, 4571, 2022
S.J. McGurnaghan, P.M. McKeigue, S.H. Read, S. Franzen, A-M. Svensson, M. Colombo, S. Livingstone, B. Farran, T.M. Caparrotta, L.A.K. Blackbourn, J. Mellor, I. Thoma, N. Sattar, S.H. Wild, S. Gudbjornsdottir and H.M. Colhoun, on behalf of the Swedish National Diabetes Register and the Scottish Diabetes Research Network Epidemiology Group Development and validation of a cardiovascular risk prediction model in type 1 diabetes Diabetologia, 64 (9), 2001-2011, 2021
S.J. McGurnaghan, A. Weir, J. Bishop, S. Kennedy, L.A.K. Blackbourn, D. McAllister, S. Hutchinson, T.M. Caparotta, J. Mellor, A. Jeyam, J.E. O'Reilly, S. Wild, S. Hatam, A. Höhn, M. Colombo, C. Robertson, N. Lone, J. Murray, E. Butterly, J. Petrie, B. Kennon, R. McCrimmon, R. Lindsay, E. Pearson, N. Sattar, J. McKnight, S. Philip, A. Collier, J. McMenamin, A. Smith-Palmer, D. Goldberg, P.M. McKeigue, H.M. Colhoun, Public Health Scotland COVID-19 Health Protection Study Group, Scottish Diabetes Research Network Epidemiology Group Risks of and risk factors for COVID-19 disease and development of a risk prediction model in people with diabetes in Scotland: A cohort study Lancet Diabetes & Endocrinology, 9 (2), 82-93, 2021
M. Colombo°, A. Asadi Shehni°, I. Thoma, S.J. McGurnaghan, L.A.K. Blackbourn, H. Wilkinson, A. Collier, A.W. Patrick, J.R. Petrie, P.M. McKeigue, R. Saldova and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators Quantitative levels of serum N-glycan in type 1 diabetes and their association with kidney disease Glycobiology, 31 (5), 613-623, 2021
M.L. Marcovecchio, M. Colombo, R.N. Dalton, P.M. McKeigue, P. Benitez-Aguirre, F. Cameron, S.T. Chiesa, J. Couper, M. Craig, D. Daneman, E. Davis, J. Deanfield, K. Donaghue, T.W. Jones, F.H. Mahmud, S.M. Marshall, H.A.W. Neil, H.M. Colhoun and D. Dunger Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes Pediatric Diabetes, 21 (7), 1322-1332, 2020
M.C. Barbu, A. Spiliopoulou, M. Colombo, P.M. McKeigue, T.-K. Clarke, D.M. Howard, M.J. Adams, X. Shen, S.M. Lawrie, A.M. McIntosh and H.C. Whalley Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging Translational Psychiatry, 10, 55, 2020
M. Colombo, S.J. McGurnaghan, L.A.K. Blackbourn, R.N. Dalton, D. Dunger, S. Bell, J.R. Petrie, F. Green, S. MacRury, J.A. McKnight, A. Collier, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes Diabetologia, 63 (4), 788–798, 2020
M. Colombo, S.J. McGurnaghan, S. Bell, F. McKenzie, A.W. Patrick, J.R. Petrie, J.A. McKnight, S. MacRury, J. Traynor, W. Metcalfe, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus Diabetologia, 63 (3), 636-647, 2020
P.M. McKeigue, A. Spiliopoulou, S.J. McGurnaghan, M. Colombo, L.A.K. Blackbourn, T.J. McDonald, S. Onengut-Gomuscu, S.S. Rich, C.N.A. Palmer, J.A. McKnight, M.W.J. Strachan, A.W. Patrick, J. Chalmers, R.S. Lindsay, J.R. Petrie, S. Thekkepat, A. Collier, S. MacRury and H.M. Colhoun Persistent C-peptide secretion in type 1 diabetes and its relationship to the genetic architecture of diabetes BMC Medicine, 17 (1), 165, 2019
M. Colombo°, E. Valo°, S.J. McGurnaghan, N. Sandholm, L.A.K. Blackbourn, R.N. Dalton, D. Dunger, P.H. Groop, P.M. McKeigue, C. Forsblom and H.M. Colhoun, on behalf of the SDRNT1BIO Investigators and FinnDiane Study Group Biomarkers associated with progression of renal disease in type 1 diabetes Diabetologia, 62 (9), 1616-1627, 2019
A. Spiliopoulou, M. Colombo, D. Plant, J. Cui, M.J.H. Coenen, K. Ikari, H. Yamanaka, S. Saevarsdottir, L. Padyukov, S.L. Bridges Jr, R.P. Kimberly, Y. Okada, P.L.C.M. van Riel, I.E. van der Horst-Bruinsma, N. de Vries, P.P. Tak, K. Ohmura, H. Canhao, K-J. Guchelaar, T.W.J. Huizinga, L.A. Criswell, S. Raychaudhuri, M. Weinblatt, A.G. Wilson, X. Mariette, J. Isaacs, A.W. Morgan, MATURA Consortium, C. Pitzalis, A. Barton and P.M. McKeigue Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 Annals of the Rheumatic Diseases, 78, 1055-1061, 2019
E.M.A. Hensor, P.M. McKeigue, S.F. Ling, M. Colombo, J.H. Barrett, J.L. Nam, J. Freeston, M.H. Buch, A. Spiliopoulou, F. Agakov, S. Kelly, M.J. Lewis, S.M.M. Verstappen, A.J. MacGregor, S. Viatte, A. Barton, C. Pitzalis, P. Emery, MATURA consortium, IACON consortium, PEAC consortium, P.G. Conaghan and A.W. Morgan Validity of a 2-component imaging-derived disease activity score for improved assessment of synovitis in early rheumatoid arthritis Rheumatology, 58 (8), 1400-1409, 2019
M. Colombo°, H.C. Looker°, B. Farran, S. Hess, L. Groop, C.N.A. Palmer, M.J. Brosnan, R.N. Dalton, M. Wong, C. Turner, E. Ahlqvist, D. Dunger, F. Agakov, P. Durrington, S. Livingstone, J. Betteridge, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT investigators Serum kidney injury molecule 1 and beta-2-microglobulin perform as well as larger panels for prediction of rapid decline in renal function in type 2 diabetes Diabetologia, 62 (1), 156-168, 2019
S. Cherlin, D. Plant, J.C. Taylor, M. Colombo, A. Spiliopoulou, E. Tzanis, A.W. Morgan, M.R. Barnes, P.M. McKeigue, J.H. Barrett, C. Pitzalis, A. Barton, MATURA Consortium and H.J. Cordell Prediction of treatment response in rheumatoid arthritis patients using genome-wide SNP data Genetic Epidemiology, 42, 754-771, 2018
J. Massey, D. Plant, K. Hyrich, A.W. Morgan, A.G. Wilson, A. Spiliopoulou, M. Colombo, P.M. McKeigue, J. Isaacs, H. Cordell, C. Pitzalis, A. Barton, BRAGGSS, MATURA Consortium Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis The Pharmacogenomics Journal, 18, 657-664, 2018
M. Colombo°, H.C. Looker°, B. Farran, F. Agakov, M.J. Brosnan, P. Welsh, N. Sattar, S.J. Livingstone, P.N. Durrington, D.J. Betteridge, P.M. McKeigue and H.M. Colhoun Apolipoprotein CIII and N-terminal prohormone b-type natriuretic peptide as independent predictors for cardiovascular disease in type 2 diabetes Atherosclerosis, 274, 182-190, 2018
J.C. Taylor, T. Bongartz, J. Massey, B. Mifsud, A. Spiliopoulou, I.C. Scott, J. Wang, M. Morgan, D. Plant, M. Colombo, P. Orchard, S. Twigg, I.B. McInnes, D. Porter, J.E. Freeston, J.L. Nam, H.J. Cordell, J.D. Isaacs, J.L. Strathdee, D. Arnett, M.J.H. de Hair, P.P. Tak, S. Aslibekyan, R.F. van Vollenhoven, L. Padyukov, S.L. Bridges, C. Pitzalis, A.P. Cope, S.M.M. Verstappen, P. Emery, M.R. Barnes, F. Agakov, P.M. McKeigue, T. Mushiroda, M. Kubo, R. Weinshilboum, A. Barton, A.W. Morgan and J.H. Barrett, on behalf of the MATURA and PAMERA Consortia Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients The Pharmacogenomics Journal, 18, 528-538, 2018
M.L. Bermingham°, M. Colombo°, S.J. McGurnaghan, L.A.K. Blackbourn, F. Vučković, M. Pučić Baković, I. Trbojević-Akmačić, G. Lauc, F. Agakov, A. Agakova, C. Hayward, L. Klarić, C.N.A. Palmer, J.R. Petrie, J. Chalmers, A. Collier, F. Green, R.S. Lindsay, S. MacRury, J.A. McKnight, A.W. Patrick, S. Thekkepat, O. Gornik, P.M. McKeigue and H.M. Colhoun, on behalf of the SDRN Type 1 Bioresource Investigators N-glycan profile and kidney disease in type 1 diabetes Diabetes Care, 41 (1), 79-87, 2018
N. Pirastu, P.K. Joshi, P.S. de Vries, M.C. Cornelis, P.M. McKeigue, N. Keum, N. Franceschini, M. Colombo, E.L. Giovannucci, A. Spiliopoulou, L. Franke, K.E. North, P. Kraft, A.C. Morrison, T. Esku and J.F. Wilson GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk Nature Communications, 8, 1584, 2017
J.D. Quell, W. Römisch-Margl, M. Colombo, J. Krumsiek, A.M. Evans, R. Mohney, V. Salomaa, U. de Faire, L.C. Groop, F. Agakov, H.C. Looker, P.M. McKeigue, H.M. Colhoun and G. Kastenmüller Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies Journal of Chromatography B, 1071, 58-67, 2017
A. Spiliopoulou, M. Colombo, P. Orchard, F. Agakov and P.M. McKeigue GeneImp: fast imputation to large reference panels using genotype likelihoods from ultralow coverage sequencing Genetics, 206 (1), 91-104, 2017
H.C. Looker°, M. Colombo°, S. Hess, M.J. Brosnan, B. Farran, R.N. Dalton, M.C. Wong, C. Turner, C.N.A. Palmer, E. Nogoceke, L. Groop, V. Salomaa, D.B. Dunger, F. Agakov, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT Investigators Biomarkers of rapid chronic kidney disease progression in type 2 diabetes Kidney International, 88 (4), 888-896, 2015
H.C. Looker, M. Colombo, F. Agakov, T. Zeller, L. Groop, B. Thorand, C.N. Palmer, A. Hamsten, U. de Faire, E. Nogoceke, S.J. Livingstone, V. Salomaa, K. Leander, N. Barbarini, R. Bellazzi, N. van Zuydam, P.M. McKeigue and H.M. Colhoun, on behalf of the SUMMIT Investigators Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes Diabetologia, 58 (6), 1363-1371, 2015
P.M. McKeigue, M. Colombo, F. Agakov, I. Datta, A. Levin, D. Favro, R.R. Burke, C. Gray-Montgomery, M.C. Iannuzzi and B.A. Rybicki Extending admixture mapping to nuclear pedigrees: application to sarcoidosis Genetic Epidemiology, 37 (3), 256-266, 2013
M. Colombo and A. Grothey A decomposition-based crash-start method for stochastic programming Computational Optimization and Applications, 55 (2), 311-340, 2013
B.A. Rybicki, A.M. Levin, P.M. McKeigue, I. Datta, C. Gray-McGuire, M. Colombo, D. Reich, R.R. Burke and M.C. Iannuzzi A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans Genes and Immunity, 12 (2), 67-77, 2011
M. Colombo, J. Gondzio and A. Grothey A warm-start approach for large-scale stochastic linear programs Mathematical Programming, 127 (2), 371-397, 2011
M. Colombo, A. Grothey, J. Hogg, K. Woodsend and J. Gondzio A structure-conveying modelling language for mathematical and stochastic programming Mathematical Programming Computation, 1 (4), 223-247, 2009
A. Grothey, J. Hogg, K. Woodsend, M. Colombo and J. Gondzio A structure-conveying parallelisable modelling language for mathematical programming "Parallel Scientific Computing and Optimization", R. Ciegis, D. Henty, B. Kågström, J. Zilinskas (eds.), Springer Optimization and its Applications, 27, 147-158, 2009
M. Colombo and J. Gondzio Further development of multiple centrality correctors for interior point methods Computational Optimization and Applications, 41 (3), 277-305, 2008

Technical reports and Dissertations

September 2020 M. Colombo, J. Mellor, H.M. Colhoun, M.G.M. Gomes and P.M. McKeigue Trajectory of COVID-19 epidemic in Europe medRxiv
June 2009, revised December 2010 M. Colombo and A. Grothey A multi-step interior point warm-start approach for large-scale stochastic linear programming Technical Report ERGO 09-007
May 2007, revised October 2007 M. Colombo Advances in interior point methods for large-scale linear programming Thesis presented for the Degree of PhD in Optimization, School of Mathematics, University of Edinburgh Successfully defended on 6 September 2007, examiners Danny Ralph and Ken McKinnon
September 2003 M. Colombo A branch-and-cut approach to solve the Hamiltonian Cycle Problem Dissertation presented for the Degree of MSc in Operational Research, School of Mathematics, University of Edinburgh MSc in OR awarded with distinction
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